A new simple, sensitive, rapid, accurate, precise and economical first derivative Spectrophotometric method for the simultaneous determination of Levosulpiride (LEVO) and Pantoprazole sodium (PANTO) in combined capsule dosage form was developed. The derivative Spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectrums were obtained in distilled Water and the determinations were made at 250.38 nm (ZCP of PANTO) for LEVO and 267.34 nm (ZCP of LEVO) for PANTO. The linearity was obtained in the concentration range of 5-45 μg/ml for LEVO and 5-45 μg/ml for PANTO The mean recovery was 97.73-101% and 99.25 – 99.75% for LEVO and PANTO respectively. The results of analysis have been validated statistically as per ICH guidelines.
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